Prof. Dr. Loránd Kiss

Research topic:
Transformation of cyclic beta-amino acids into bioactive natural products through ring-opening/ring-closing metathesis

Supervisor:
Prof. Dr. Loránd Kiss, Prof. Dr. Ferenc Fülöp

Description:
Beta-amino acids are components of bioactive natural compounds. The conformationally restricted representatives are building blocks for the synthesis of various oligopeptides.
Our research program is directed towards:
(a) synthesis of potentially bioactive functionalized beta- amino acids across ring-opening/ring- closing metathesis by starting from readily available unsaturated cyclic amino acids.
(b) selective and stereocontrolled transformation of readily available cyclic beta-amino acids by ring-opening/ring closing metathesis into potentially bioactive heterocycles or natural products.

 

Research topic:
Selective synthesis of fluorinated building blocks

Supervisor:
Prof. Dr. Loránd Kiss, Prof. Dr. Ferenc Fülöp

Description:
The number of fluorinated pharmaceuticals on the market is continuously increasing over recent years, therefore there is an increasing demand for the synthesis of fluorine containing organic scaffolds.
Our research focuses on:
(a) selective synthesis of fluorinated building elements possessing multiple stereocenters
(b) synthesis of various fluorinated beta-amino acid enantiomers as building blocks for the peptides synthesis