Prof. Dr. Ferenc Fülöp

Dr. Fülöp Ferenc

Prof. Dr. Ferenc Fülöp
D.Chem., PhD., D.Sc.,
Member of the Hungarian Academy of Sciences

Address: Szeged, Eötvös u. 6, H-6720, Hungary
Telephone: +36-62-54-5564
Fax: +36-62-545-705
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Curriculum vitae
Name: Ferenc Fülöp
Born: 23. 02. 1952, Szank, Hungary
Nationality:     Hungarian

Education and degrees

  • M.Sc.:   Organic chemistry, József Attila University, Szeged, 1975
  • Ph.D.:   Organic chemistry (thesis: Synthesis of nitrogen bridgehead heterocycles), József Attila University, Szeged, 1978
  • C.Sc.:   Organic chemistry (thesis: Synthesis and stereochemistry of 1,3-heterocycles, potential pharmacons), Hungarian Academy of Sciences, Budapest, 1983
  • D.Sc.:   Organic chemistry (thesis: Synthesis and stereochemistry of bicyclic 1,3-heterocycles), Hungarian Academy of Sciences, Budapest, 1990

Professional employment and experience

  • 1975-1979:       Ph.D. student at the Department of Organic Chemistry, József Attila University
  • 1979-1991:       Teaching appointments (assistant, lecturer, reader) at the Institute of Pharmaceutical Chemistry, Albert Szent-Györgyi Medical University
  • 1991-present:    Full professor, Institute of Pharmaceutical Chemistry, Albert Szent-Györgyi Medical University
  • 1998-present:    Head of Institute of Pharmaceutical Chemistry, Albert Szent-Györgyi
    Medical University (From January 2000 Institute of Pharmaceutical Chemistry, University of Szeged)
  • 2006-present:    Dean of Faculty of Pharmacy

Experience abroad

On 9 occasion in the past 10 years at the Department of Chemistry, University of Turku, Turku, Finland, 1-6 months each time. Department of Chemistry, University of Bonn, Bonn, Germany, 3 months in 1994. School of Chemistry, University of St. Andrews, Scotland, 2 month in 1997.

Major research interest

Synthesis and stereochemistry of saturated heterocycles, nitrogen bridgehead compounds, cycloalkane-fused 1,3-heterocycles, ring-chain tautomerism, tetrahydroisoquinoline-fused 1,3-heterocycles, synthesis of potential drugs, enantioselective reactions, b-amino acids, enzyme reactions, combinatorial chemistry, drug discovery research.

Publications: 406 research publications; 18 review articles. Independent citations: ~2500.

Patents: 18 drug patents

Lectures: 140 conference and seminar lectures in different countries, and 130 scientific lectures in Hungary

Memberships, positions in Scientific Committees and Societies

President of Csongrád-County group of the Hungarian Chemical Society; President Pharmacy Committee of the Hungarian Academy of Sciences; President of the Committee of Heterocyclic Chemistry of the Hungarian Academy of Sciences; Head of the Ph.D. program in Faculty of Pharmacy; Member of the Hungarian Chemical Society; Member of the Hungarian Pharmaceutical Society; Member of the International Heterocyclic Chemistry Society; Member of American Chemical Society.

Awards: Géza Zemplén prize, 1983; Széchenyi Professor 1997-2001. Teacher of the Year, 1998, 1999, 2000 and 2003. Charles Simonyi Award 2002, Dénes Gábor Award 2002. Károly Than Award 2005, Victor Bruckner Award 2006. Corresponding Member of Hungarian Academy of Sciences 2007. Béla Szőkefalvi-Nagy Award 2008, Khwarizmi Laurate 2009.

Ferenc Fülöp's List of Publications (MTMT)

Publications: 532 research publications; Independent citations: ~2600.
Patents: 16 drug patents

Latest oral communication

Loránd Kiss, Melinda Nonn, Enikő Forró, Santos Fustero, Ferenc Fülöp:
Synthesis of fluorinated β-aminocyclohexane-carboxylate stereo- and regioisomers
COST Meeting Foldamers 2012.
30th August - 2nd September 2012, University of Regensburg, Germany

Ferenc Fülöp
Heterocycles from cyclic b-amino acids (keynote lecture)
March 4th - 7th, 2012 Gainesville, Florida, USA

Kiss L., Fülöp F.:
Synthesis of 1,2,3-triazole-substituted cispentacin stereoisomers
XIVth Conference on Heterocycles in Bio-organic Chemistry
September 4 – 8, 2011, Brno, Czech Republic

Kiss L., ustero S., De Kimpe N., Fülöp F.:
Selective Synthesis of Highly Functionalized Cyclic β-Amino Acids
Foldamers: Synthesis and Structure of Functional Materials,
7-9th April 2011, Barcelona

Nonn M, Callebaut G, Mangelinckx S, Kiss L, Sillanpää R, Fülöp F, De Kimpe N.:
Stereoselective Mannich-type reaction of O-protected glycolate esters across N-sulfinyl α-chloro aldimines. Synthesis of α-hydroxy-β,γ-aziridino ester derivatives
Foldamers: Synthesis and Structure of Functional Materials,
7-9th April 2011, Barcelona

Ferenc Fülöp:
Cyclic b-amino acids: excellent toolkits to create bioactive products
11th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-11)
29 September - 2 October 2009, San Sebastian, Basque Country, Spain

 

Latest poster presentations

Loránd Kiss, Melinda Nonn, Reijo Sillanpää, Santos Fustero, Ferenc Fülöp:
A stereocontrolled novel synthesis of fluorinated cispentacins  
International Symposium on Fluorous Technologies 2013 (ISoFT’13),
June 2 -June 5, 2013, Budapest, Hungary

Loránd Kiss, Santos Fustero, Ferenc Fülöp:
Fluorinations around functionalized alicyclic β-amino acids
Paris 2013 Symposium on Foldamers,
April 10 - 12, 2013, Les Cordeliers - Latin Quarter - Paris - France

Cherepanova Maria, Kiss Loránd, Fülöp Ferenc:
Synthesis of novel highly functionalized cyclic b–amino acids
BOSS XIII - 13th Belgian Organic Synthesis Symposium
July 15, 2012 Leuven, Belgium

Loránd Kiss, Santos Fustero, Ferenc Fülöp:
Stereo- and Regioselective Synthesis of Difluorinated Cyclic b-amino Acid Derivatives
3rd International Symposium on Organofluorine Compounds in Biomedical, Materials and Agricultural Sciences
Valencia, Spain, from May 20-24, 2012

Melinda Nonn, Loránd Kiss, Ferenc Fülöp:
Stereo- and regioselective synthesis of fluorinated cispentacins
3rd International Symposium on Organofluorine Compounds in Biomedical, Materials and Agricultural Sciences
Valencia, Spain, from May 20-24, 2012

Loránd Kiss, Enikő Forró, Santos Fustero, Ferenc Fülöp
Selective synthesis of fluorinated β-aminocyclohexanecarboxylates
March 4th - 7th, 2012 Gainesville, Florida, USA

Palkó M, Fülöp F.:
Synthesis and transformations of alicyclic 2-amino- and 2-hydroxysulfonic acids
XIVth Conference on Heterocycles in Bio-organic Chemistry
September 4 – 8, 2011, Brno, Czech Republic

Nonn M, Kiss L, Sillanpää R, Fülöp F:
Synthesis of highly functionalized b-aminocyclopentane- or cyclohexanecarboxylate stereoisomers via selective nitril-oxide dipolar cycloaddition
XIVth Conference on Heterocycles in Bio-organic Chemistry
September 4 – 8, 2011, Brno, Czech Republic

Kiss L, Forró E, Fustero S, Fülöp F.:
Selective synthesis of fluorinated cyclic β-amino acids
12th International Congress on Amino Acids, Peptides and Proteins
August 1-5, 2011, Beijing, China

 Kiss L, Forró E, Fülöp F.:
Stereoselective Synthesis of Novel Highly Functionalized β-Aminocyclohexane-carboxylic Acids
Twelfth Tetrahedron Symposium. Challenges in Organic and Bioorganic Chemistry
21-24th June 2011, Sitges, Spain

Schönstein L, Forró E, Kiss L, Peñaloza A.V, Juaristi E, Fülöp F.:
Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated β-amino ester stereoisomers
Foldamers: Synthesis and Structure of Functional Materials,
7-9th April 2011, Barcelona

Loránd Kiss, Enikő Forró, Brigitta Kazi, Ferenc Fülöp:
Synthesis of novel conformationally constrained N-containing cyclic beta-amino acids
XXIVth European Colloquium on Technical University Vienna, August 23 - 27, 2010

Éva Szolnoki, Zsófia Hegedüs, Zsolt Szakonyi, Tamás A. Martinek, Ferenc Fülöp:
Effects of bicyclic residues on β-peptide secondary structures
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Loránd Kiss, Enikő Forró, Ferenc Fülöp:
Synthesis of multifunctionalized 1,2,3-triazole-modified carbanucleoside analogues via azide-alkyne dipolar cycloaddition
11th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-11)
29 September - 2 October 2009, San Sebastian, Basque Country, Spain

István M. Mándity, Lívia Fülöp, Elemér Vass, Gábor K. Tóth, Tamás A. Martinek, Ferenc Fülöp:
Effects of side-chain topology and entropy on the self organization of β-peptides
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

László Schönstein, Enikő Forró, Loránd Kiss, Ferenc Fülöp:
Enzymatic hydrolysis of hydroxylated alicyclic β-amino esters
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Gábor Tasnádi, Enikő Forró, Ferenc Fülöp:
An improved enzymatic method for the preparation of valuable β-arylalkyl-β-amino acid enantiomers
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Gabriella Benedek, Márta Palkó, Edit Wéber, Tamás A. Martinek, Enikő Forró, Ferenc Fülöp:
Efficient syntheses of hydroxy-substituted 2-aminocyclohexanecarboxylic acids
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Brigitta Kazi, Loránd Kiss, Enikő Forró, Ferenc Fülöp:
Preparation of orthogonally protected piperidine and azepane b-amino ester enantiomers
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Zsolt Szakonyi, Reijo Sillanpää, Ferenc Fülöp:
Sztereoselective synthesis and transformations of the enantiomers of apopinane-based b-amino acids
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Melinda Nonn, Lorand Kiss, Enikő Forró, Ferenc Fülöp:
Regio- and stereoselective 1,3-dipolar cycloaddition of nitrile oxides to ethyl cis- or trans-2-aminocyclopent-3-enecarboxylates
Foldamers: building blocks, structure and function,
24-26th September, 2009, Szeged, Hungary

Gábor Tasnádi, Enikő Forró, Ferenc Fülöp
Lipase PS-catalysed hydrolysis of β-heteroaryl-substituted β-amino esters
16th European Symposium on Organic Chemistry,2009. július 12-16, Prága, Cseh Köztársaság, :

 Enikő Forró, Ferenc Fülöp :
A new enzymatic method for the synthesis of blockbuster drug intermediates - synthesis of five-membered cyclic g-amino acid and g-lactam enantiomers
Zing Asymmetric Synthesis Conference 2009
Antigua - Barbuda, January 18 - 21, 2009

Gabriella Benedek, Márta Palkó, Edit Wéber, Tamás A. Martinek, Enikő Forró, Ferenc Fülöp
Efficient Syntheses of Hydroxy-Substituted Cispentacin Derivatives
XXIIIrd European Colloquium on Heterocyclic Chemistry, (ECHC 08) 2008
Antwerp - Belgium - September 9 - 13, 2008

Brigitta Kazi, Loránd Kiss, Enikő Forró, Ferenc Fülöp:
A new strategy for the preparation of orthogonally protected N-heterocyclic b-amino esters
XXIIIrd European Colloquium on Heterocyclic Chemistry, (ECHC 08) 2008
Antwerp - Belgium - September 9 - 13, 2008

Edina Vigóczki, István Mándity, László Lázár, Ferenc Fülöp:
Synthesis Of Nitrogen-Bridged Polycycles By Domino Ring-Closures
XXIIIrd European Colloquium on Heterocyclic Chemistry, (ECHC 08) 2008
Antwerp - Belgium - September 9 - 13, 2008

Loránd Kiss, Enikő Forró, Reijo Sillanpää and Ferenc Fülöp:
Synthesis of functionalized d-amino alcohol stereoisomers with a cyclopentane skeleton. Hydroxylated azidocarbanucleoside precursors
Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th Symposium on Nucleic Acids Chemistry
September 8-12, 2008, Kyoto, Japan

Anasztázia Hetényi, Gábor K. Tóth, Csaba Somlai, Elemér Vass, Tamás A. Martinek, Ferenc Fülöp:
Structural characterization of H-[( or )-cis trans ACPC-2S-aza-ACPC]3-NH2
30th European Peptide Symposium (30EPS),
Finlandia Hall, Helsinki, Finland, 31 August – 5 September 2008

Zsolt Szakonyi, Tamás A. Martinek, Ferenc Fülöp:
Regio- and Stereoselective Synthesis of The Enantiomers of Apopinane-Based b-Amino Acids
20th International Symposium on Chirality, 2008. július 6-9,Genf, Svájc

Gábor Tasnádi, Enikő Forró, Ferenc Fülöp:
Enantioselective hydrolysis of ethyl 3-amino-3-arylpropionates
20th International Symposium on Chirality, 2008. július 6-9,Genf, Svájc

István Szatmári and Ferenc Fülöp:
Application of the Betti Reaction for the Synthesis of New Chiral Ligands
21st International Congress for Heterocyclic Chemistry (ICHC21)
The University of New South Wales, Sydney, Australia, 15-20 July 2007

Tihamér A. Paál, Arto Liljeblad, Enikő Forró, Ferenc Fülöp, Liisa T. Kanerva:
The First Enzyme-Catalyzed Kinetic and Dynamic Kinetic Resolution of 1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Derivatives
8th International Symposium on Biocatalysis and Biotransformations (Biotrans 2007)
8 to 13 July 2007 in Oviedo, Spain

Árpád Balázs, Zsolt Szakonyi, Anasztázia Hetényi, Ferenc Fülöp:
Synthesis of Cyclohexane-Fused Six- and Eight-Membered Heterocycles via Pd(II)-Catalyzed Oxidative Amination
15th European Symposium on Organic Chemistry,
Dublin, Ireland, 8th - 13th July, 2007

Iván Kanizsai, Zsolt Szakonyi, Ferenc Fülöp:
Synthesis and tandem cyclisation of alicyclic β-aminonitriles towards imidazolo- and pyrimidopyrimidines
lue Danube Symposia on Heterocyclic Chemistry (BDSCH) 12
June 10-13, Tihany, Hungary

Gabriella Benedek, Márta Palkó, Loránd Kiss, Tamás A. Martinek, Ferenc Fülöp:
Efficient syntheses of hydroxy-substituated b-aminocyclopentanecarboxylic acids
Blue Danube Symposia on Heterocyclic Chemistry (BDSCH) 12
June 10-13, Tihany, Hungary