Name: Ruba Ismail
Birth of Date, Birth of Place: 07-Sep-1989, Latakia-Syria
Address: Institute of pharmaceutical technology and regulatory affairs, Faculty of Pharmacy, Universitiy of Szeged 6 Eötvös Str. H-6720 Szeged
*September 2016-now: Ph.D. candidate Supervisor: Dr. Ildikó Csóka
Project: Quality by design-oriented study for developing nanocarriers for oral delivery of GLP-1 analogue
Institute of Pharmaceutical technology and regulatory affairs, Faculty of Pharmacy, University of Szeged -Szeged, Hungary.
*April 2019-May 2019: Research fellow Supervisors: Prof. Andreas Bernkop Schnurch; Dr. Ildikó Csóka
Project: Design of SEDDS for oral GLP-1 analogue-exenatide- delivery
Pharmaceutical technology department, Institute of pharmacy, University of Innsbruck, Innsbruck, Austria
* February 2016: Syrian Board certificate in pharmaceutical sciences - drug design and control.
*December 2012-July 2015 : Master Degree MSc. in pharmaceutical sciences (Drug design and control).
Supervisor: Dr. Faten Madani; Co-supervisor: Dr. Tamim Hammad
Thesis: Formulation of methyldopa sustained release matrix tablets using hydrophilic polymers
Department of Pharmaceutics & Pharmaceutical technology, Faculty of Pharmacy, Tishreen University-Latakia, Syria.
*October 2007- July 2012: Bachelor Degree BSc. of pharmacy and pharmaceutical chemistry.
Faculty of Pharmacy , Tishreen University-Latakia, Syria.
- Ildiko Csoka (PhD supervisor)
Head of the Institute of Pharmaceutical technology and regulatory affairs, Faculty of Pharmacy, University of Szeged -Szeged, Hungary.
Field of Search
My research interests include the invasive delivery of biologics, pharmaceutical nanotechnology, modified drug delivery systems and regulatory affairs.
Arabic (mother tongue), English (fluent), Hungarian (intermediate level), German (intermediate level).
*Very good experience at giving presentations to large audiences of people, gained through both teaching at university and making several seminars during my previous academic years.
*Very good experience with Internet and search, Microsoft office (International Computer Driving ICDL certificate).
*Very good experience with statistical softwares (SAS, STATISTICA)
*Highly Experienced with conducting initial risk assessment based study (Lean QbD software), and design of experiments (DoE).
*Good experience with analytical techniques, e.g. HPLC, LC-MS, UV-Vis, XRPD, DSC, FT-IR, CD.
*Highly experienced in planning and execution of in vitro, ex vivo and in-vivo research activities.
Attended Conferences (oral presentations/posters)
-EUFEPS. Frankfurt, Germany, 2019.
-3rd International Symposium on Scientific and Regulatory Advance in Biological and Non-Biological Complex Drugs: a to z in -bioequivalence,” Budapest, Hungary,2018.
-CESPT. Szeged, Hungary,2018.
-11th Conference on Colloid Chemistry -11CCC, Eger, Hungary, 2018
-9th Int. Congress Nanotechnology in Biology & Medicine. Graz, Austria, 2018
-1st Young Technologists’ Forum organised by the Hungarian Society for Pharmaceutical Sciences Pharmaceutical Technology Section, Budapest, 2018
-11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Granada, Spain, 2018.
-7th BBBB International Conference on Pharmaceutical Sciences, Balatonfüred, Hungary 2017.
-13th International Conference and Exhibition Nanomedicine and pharmaceutical nanotechnology, Rome, Italy 2017.
-Pharmaceutical Sciences Innovations, Annual Conference, Latakia, Syria, 2016.
-Pharmaceutical Sciences Innovations, Annual Conference, Latakia, Syria 2015.
-Pharmaceutical Sciences Innovations, Annual Conference, Latakia, Syria 2014.
-Botanical Therapy & its importance in Medicine world, Latakia, Syria 2013.
-Pharmaceutical Sciences Innovations, Annual Conference, Latakia, Syria 2010.
Published papers and conference abstracts
Ruba Ismail, Alexandra Bocsik, Gabor Katona, Ilona Grof, Maria Deli, Ildikó Csóka, Encapsulation in polymeric nanoparticles enhances the enzymatic stability and the permeability of GLP1 analog- liraglutide across a culture model of intestinal permeability. Pharmaceutics. 2019.
Fakhara Sabir, Ruba Ismail, Ildikó Csóka. “Nose to brain delivery of anti-glioblastoma drugs embedded into lipid nanocarrier system: status quo and outlook,” Drug discovery today. 2019. https://doi.org/10.1016/j.drudis.2019.10.005
Ruba Ismail, Tamás Sovány, Attila Gácsi, Rita Ambrus, Gábor Katona, Norbert Imre, Ildikó Csóka. “Synthesis and statistical optimization of poly (lactic-co-glycolic acid) nanoparticles encapsulating GLP-1 analog designed for oral delivery,” Pharm. Res., 63:99,2019.
Ildikó Csóka, Gabor Katona, Dobo Dorina, Ruba Ismail, Reyhaneh Manteghi, Edina Pallagi. “Colloidal systems as carriers for peptide drugs: possibilities and challenges,” EUFEPS. Frankfurt, Germany,2019.
Ruba Ismail and Ildikó Csóka. “Design of experiment DOE based methodology for designing polymeric NPs encapsulating Liraglutide for oral delivery,” CESPT. Szeged, Hungary,2018.
Ildikó Csóka, Gabor Katona, Ruba Ismail, Edina Pallagi. “Expectations and limits of colloidal systems as carriers for peptide drugs,” 3rd International Symposium on Scientific and Regulatory Advance in Biological and Non-Biological Complex Drugs: a to z in bioequivalence,” Budapest, Hungary,2018.
Edina Pallagi, Ruba Ismail, Tamás Paál, Ildikó Csóka. “Initial Risk Assessment as part of the Quality by Design in peptide drug containing formulation development,” Eur J Pharm Sci.,122, 160–169, 2018.
Ruba Ismail and Ildikó Csóka. “Pharmaceutical applications of colloidal drug delivery systems: case studies for biological drugs,” 11CCC, Eger, Hungary,2018.
Ruba Ismail and Ildikó Csóka. “Initial SWOT analysis of designing polymeric nanoparticles and lipid- based nanoparticles for oral GLP-1 analog delivery,” Bionanomed, Graz, Austria,2018.
Ruba Ismail and Ildikó Csóka. “Quality by design (QbD) oriented study for designing oral Liraglutide loaded polymeric nanoparticles,”11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology- Granada, Spain,2018.
Ruba Ismail and Ildikó Csóka. “Evaluation of techniques and possibilities for oral delivery of antidiabetic peptide drug -liraglutide- in a novel delivery system,” Acta pharmaceutica Hungarica 3-4,132-133,2017.
Ruba Ismail and Ildikó Csóka. “Up to date advances in nano-carrier systems for oral delivery of antidiabetic peptides,” J. Nanomed. Nanotechnol., 8, p. 63,2017.
Ruba Ismail and Ildikó Csóka. “ Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP1 and its analogs, ” Pharm Biopharm.,115,257-267,2017
Ruba Ismail. “Novel methyldopa extended release matrix tablets,” J. Int. Res. Med. Pharm. Sci., 8,64-37,2016.
Ruba Ismail, Faten Madani, Tamim Hammad. “Formulation of Once daily methyldopa sustained release matrix tablets,” Res. J. Pharm. Technol., 8,161-166,2015
Ruba Ismail, Thi Nhu Quynh Phan, Flavia Laffleur, Ildikó Csóka, Andreas Bernkop-Schnürch. In vivo evaluation of a self-emulsifying drug delivery system (SEDDS) designed for oral exenatide delivery. J (To be submitted).
Hussein Akel, Ruba Ismail, Ildikó Csóka. Progress and perspectives in brain targeting lipid based nanosystems via the nasal route in Alzheimer's disease. Eur. J. Pharm. Biopharm. (under revision)